Friday, February 6, 2009

Lifestyle Changes to Increase Telomerase

US News and World Report had a story last week about boosting telomerase through diet, exercise and stress reduction.

Specifically, he found that telomerase was boosted by 30 percent in prostate cancer patients who followed a plant-based, whole-grain diet with very little fat or sugar for three months. The men also took fish oil supplements, did daily 30-minute bouts of exercise, and practiced yoga or meditation for an hour a day. "Telomerase turns up those genes associated with disease prevention and turns down the genes associated with heart disease, diabetes, and cancer," explains Ornish.

Just an ounce. The "pound of cure" lifestyle approach examined in his study may not be necessary for healthier folks, he says. They may need only an ounce of prevention to maintain their telomerase levels: switching from regular to nonfat dairy products; adding two or three servings of fruits and vegetables to their diet, for example; or doing just a few minutes of daily meditation.

What if you have already done those things are you still have short telomeres? Until there is a pharmaceutical solutions, herbal supplements of TA-65 might be the solution. Off to meditate now!

Monday, February 2, 2009

Blackburn Video

Dr. Elizabeth Blackburn, Professor of Biology and Physiology in the Department of Biochemistry and Biophysics at the University of California, San Francisco, is expert in the area of telomere and telomerase research. She talks about how we actually age.

There is an extensive discussion of telomerase.

Friday, January 30, 2009


I was reading the comments on this Newsweek article about life extension and got a little annoyed. Comments like this are easy to make when you are young and healthy:

Getting older and staying alive with drugs sounds so unnatural. I am 32 years old I have never taken any kind of real hard drugs prescribed or other wise and I look like I am no older than 17 years old if not younger.
I myself am 32 years old and can pass for mid twenties. But now that I am a mother of 2 small children, I have really come to fear death in a way that is new and unfamiliar to me. I want to be here to see my children grow, marry, have kids and see great-grandchildren. And I want my parents too to be able to live long enough to see great-grandchildren. I love my husband and I want to spend many, many more years with him.

Not only do I want to live a long time ( and have my loved ones live long too), I want us all to be in good health. There is no use in being old if you are not healthy and vibrant as well. It looks like TA-65 can do that for some people. And if you can afford the $18,000 to add years to your life (and life to your years) then who are we to judge if that money is well spent? Or it its "wrong" or "unnatural" to do so?

Tuesday, January 27, 2009

Geron to implant embryonic stem cells into humans

Geron Corp., a California-based biotech company, has been given the OK to implant embryonic stem cells in eight to 10 paraplegic patients who can use their arms but can't walk. Stem cell injections will be given within two weeks of the injury. The study will begin this summer, and will be conducted at up to seven different medical centers.
This is the same Geron that discovered TA-65. Geron is reportedly also working on other telomerase activators.

Monday, January 12, 2009

Who is Noel Patton

I read the bio of Noel Patton, founder of T.A. Sciences on his site, but this article gave some more insight into what prompted him to get into the business of telomerase activation.

Mr. Patton had never heard of telomeres until he attended a black-tie dinner to raise funds for aging research in Palm Desert, Calif., in 1999.

By then, he had spent about four years searching for a doctor to provide him "with some decent anti-aging care." But for the most part, he said, he encountered hucksters. Then he listened to Jerry Shay, a noted cell biologist from the University of Texas Southwestern Medical Center, give a talk on telomeres.

Dr. Shay, whose research helped produce the telomere theory of aging, described how activating an enzyme known as a telomerase "might be able to extend the lifespan of telomeres and immortalize cells."

Telomerase is usually turned off in normal cells. But the gene that produces it is usually turned on in stem cells and cancer cells — both of which are theoretically "immortal," having the ability to multiply indefinitely.

Mr. Patton immediately approached Dr. Shay, who told him that the University of Texas had licensed its telomere work to the California-based Geron Corp., an influential biotech firm that co-discovered the telomerase gene in 1997 and backed the early work on human stem cells.

The next morning, Mr. Patton called Geron's CEO and made a major investment in the company. He learned that it was hunting for a compound to boost telomerase and had started talks with researchers at the University of Science and Technology in Hong Kong to look into compounds from China.

As it happened, Mr. Patton was also based in Hong Kong, where he had moved with his wife, Eve, and their two children in 1987 after deciding to manufacture some of his fan and heater parts in mainland China. From there, he was able to help facilitate an agreement with the Hong Kong scientists to test 50 compounds from traditional Chinese medicine.

One candidate was astragalus, a spiky shrub from Inner Mongolia that the Chinese have used for thousands of years as an immune-system booster, blood-pressure controller and overall wellness agent. They add it to stews and soups and boil it as a tea. Health-food stores carry extracts.

When it was tested, according to Mr. Patton, the scientists found that the plant did indeed boost the human cell's telomerase activity.

At the time, however, developing an astragalus drug was not a priority for Geron, which was concentrating its efforts on cancer and stem cells.

Mr. Patton didn't want to wait.

In 2002, he formed his own company, TA Sciences, in Manhattan (where he now lives part-time). He struck a deal with Geron for a worldwide licence on an astragalus plant extract for non-drug purposes. By billing his planned product as an dietary supplement and making no disease-curing claims, he could develop his alternative medicine free of the time-consuming regulatory processes of the U.S. Food and Drug Administration.

Read more

Saturday, December 27, 2008

Telomere article from 2003

I had no idea that people have been talking about telomerase activation since 2003. Maybe even earlier.

Check out this article from January 2003.

Could extending telomeres, those bits of DNA at the ends of chromosomes in cells, prolong lives?

Some scientists think so.

Researchers in the United States, who discovered that elderly people with longer telomeres lived five to six years longer than people with shorter ones, think increasing the length of telomeres could be a possible key to a longer life.

Friday, December 12, 2008

Does TA-65 really cost $25,000??

From Newsweek magazine
Telomere biologist Bill Andrews of Sierra Sciences is taking a telomerase-boosting supplement called TA-65. "I believe it's safer than driving my car to work," he says. Since he started taking it a year and a half ago, Andrews says he has moved from the back of the pack to the front in 100-mile runs known as ultramarathons. But don't expect to find TA-65 at your local Vitamin Shoppe. It is available only from TA Sciences—for $25,000 a year.
Newsweek has it wrong. TA-65 costs less than $25,000. Prices are listed on the Patton Protocol page. And a good part of the fees come from testing your biomarkers of aging.